After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.

The Chief has disappeared and the only clue that the team has to his whereabouts is an average donkey.

Following the only lead in the search for Niles Caulder, the Doom Patrol sets out for Paraguay and discovers Dr. Von Fuchs, the Nazi doctor who transformed Eric Morden into Mr. Nobody, and learns the connection between Niles and the two villains.

As the team recovers from the fight at Fuchtopia, Willoughby Kipling, an old friend of Niles', unexpectedly conscripts the Doom Patrol into helping him avert the end of the world by stopping a cult, but the team fails and the apocalypse begins.

Following a clue left by Mr. Nobody, Jane, Larry and Rita visit a school where Niles' previous team of heroes -- the original Doom Patrol -- has retired; Cliff and Vic tenuously bond over their mutual "father issues."