Break On Through

The nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves; Meredith's mistake in treating an elderly patient is brought to light by the patient's friends (June Lockhart, Betty Garrett and Rae Allen) and Izzie treats a pregnant teen.

Much Too Much

Meredith is mortified when her "one night stand" shows up at the hospital suffering from priapism and needing medical attention; a woman carrying quintuplets is overwhelmed by numerous medical issues as she navigates her high-risk pregnancy; and Alex's shortcomings frustrate Izzie.

Enough Is Enough

When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems. Meanwhile, as Dr. Webber recovers from brain surgery, it seems that his wife (guest starring Loretta Devine as Mrs. Webber) has some concerns about the state of their marriage.

Who's Zoomin' Who?

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting. Meanwhile, the chief reluctantly confides to Dr. (Derek) Shepherd about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; and, just as Meredith and Derek grow more intimate, a bombshell is dropped.

Owner of a Lonely Heart

Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.